Buffalo Bills vs Miami Dolphins prediction: Will Miami finally win or will Josh Allen dominate again?

Josh Allen and the Buffalo Bills will play Tua Tagovailoa and the Miami Dolphins on Thursday, September 18, 2025, at Highmark Stadium in Orchard Park, New York. The Bills are 2-0 and want to stay unbeaten. The Dolphins are 0-2 and want to stop their losing streak.

Kickoff is at 8:15 p.m. ET on Thursday Night Football. Buffalo is the heavy favorite, but Miami still hopes to shock everyone.

Josh Allen to Play with Helmet Visor

Buffalo quarterback Josh Allen broke his nose in the last game against the New York Jets. To protect himself, he will wear a clear helmet visor on Thursday. Even with the injury, Allen is expected to play at full strength. He has a strong record against Miami, with 45 touchdowns in 15 career games.

Analysts believe he will attack Miami’s defense, which has already given up many big plays this season.

Tua Tagovailoa needs big night for Miami Dolphins

Miami quarterback Tua Tagovailoa has had a rough start to the season. His team has lost two games in a row, and their defense has given up an average of 33 points each game. Miami will miss tight end Darren Waller and cornerback Storm Duck, while wide receiver Jaylen Waddle is questionable with a shoulder injury. Without these players, Tagovailoa will need to rely on quick passes and smart plays.

Miami head coach Mike McDaniel said the short week is “a blessing” because it lets them focus only on Buffalo.

Matt Milano and Ed Oliver out for Buffalo Bills

The Bills will also play without some key defenders. Linebacker Matt Milano is out with a pectoral injury, and defensive tackle Ed Oliver has an ankle injury. Cornerbacks Taron Johnson and Cam Lewis are questionable. Even with these losses, Buffalo’s defence has been strong. Playing at home, they will try to pressure Tagovailoa and stop Miami’s run game early.

Jaylen Waddle could change the game

Wide receiver Jaylen Waddle may still play if his shoulder holds up. If he does, he could give Miami a big boost. Waddle’s speed can break through Buffalo’s secondary, which is also dealing with injuries. Also Read: Will Josh Allen Play Against The Miami Dolphins Tonight? Latest Injury Update On The Buffalo Bills' QuarterbackIf Waddle connects well with Tagovailoa, Miami could have a chance to score quickly. But if he cannot play, Buffalo’s defence will likely control the game.Buffalo Bills is favored by more than 12 points and has won six straight games against Miami at home. The Bills want to stay unbeaten, while the Dolphins want to avoid an 0-3 start. With Allen’s strong history against Miami and Waddle’s injury status, this game could decide the early momentum of both teams’ seasons.