Philadelphia 76ers vs Cleveland Cavaliers regular season game injury report, who's out, and key impact analysis (Nov 5, 2025)

The Philadelphia 76ers and Cleveland Cavaliers meet on November 5, 2025, in what promises to be a compelling regular season clash filled with injury-driven storylines. Both teams have dealt with key absences in recent weeks, and this matchup could mark a turning point as several players return to action while others continue to rest or recover.For Philadelphia 76ers, it’s a critical test of endurance as they navigate a back-to-back set, while Cleveland looks to regain momentum behind returning stars. The game is not just about standings but about resilience, adaptation, and finding balance in the face of roster challenges. Let’s take a closer look at the detailed injury updates, potential rotations, and how these factors could shape tonight’s contest.

Philadelphia 76ers Injury Report (Nov 5, 2025)

The Philadelphia 76ers enter this matchup with a depleted roster and a demanding schedule. Joel Embiid, the reigning MVP and team cornerstone, is listed as questionable, but reports indicate he will likely sit out to manage his ongoing left knee issues. Embiid has been vocal about prioritizing long-term health, especially after surgery, and has avoided playing back-to-back games this season. His absence leaves a massive void in both interior defense and offensive production.

Paul George remains out as he continues recovery from offseason knee surgery, thinning the Philadelphia 76ers’ wing rotation even further. Forward Dominick Barlow has been ruled out due to an elbow injury, while rookie guard Jared McCain is questionable after returning from a lengthy injury layoff. McCain saw limited minutes in the previous outing, and the coaching staff is expected to manage his workload carefully.

Despite the injury setbacks, the Sixers have shown determination, relying on younger talents and key role players to carry the load. However, facing Cleveland without Embiid and George significantly challenges their depth and frontcourt strength.

Cleveland Cavaliers Injury Report (Nov 5, 2025)

The Cleveland Cavaliers, sitting at 4-3, come into this game with optimism as several key players near full recovery. Forward De’Andre Hunter, who began the season on the sidelines with a preseason knee issue, is questionable due to illness but remains a vital contributor when healthy.The biggest boost for Cleveland could come from star point guard Darius Garland, who is questionable but widely expected to make his season debut following toe surgery in the offseason. His return would greatly enhance the Cleveland Cavaliers’ offensive rhythm, providing playmaking support alongside Donovan Mitchell.Center Jarrett Allen is also questionable with a fractured finger and will be a game-time decision.

Meanwhile, Max Strus remains out following foot surgery, and Sam Merrill’s availability is uncertain due to a hip contusion. Despite these concerns, the Cavs are trending in the right direction with several key pieces nearing return.

Philadelphia 76ers vs Cleveland Cavaliers Game Impact

This matchup’s dynamics hinge heavily on player availability. Without Embiid, the 76ers must rely on Tyrese Maxey and Kelly Oubre Jr. to carry the offensive load. Their performance could determine whether Philadelphia 76ers can stay competitive against a Cleveland team potentially bolstered by Garland’s return.The back-to-back schedule adds another layer of complexity for the Sixers, who will need to rotate strategically and manage fatigue. Conversely, Cleveland could benefit from fresh legs and improved chemistry as returning players reintegrate into the lineup. If Garland and Allen both play, the Cleveland Cavaliers could gain a significant advantage in playmaking and rebounding.

Where to Watch Tonight's Philadelphia 76ers vs Cleveland Cavaliers Game (November 5, 2025)

Fans can tune in to the action on Wednesday at 7 p.m. ET, available via local broadcast and streaming platforms.

The matchup offers an early-season test of endurance and adaptability for both teams, blending comeback narratives with competitive intensity.As the Philadelphia 76ers and Cleveland Cavaliers gear up for battle, the focus will remain on how each team adjusts to its injury circumstances. Whether the Sixers can overcome adversity or the Cavaliers capitalize on renewed health will determine which side emerges victorious in this pivotal early-season showdown.