Scientists of Mysuru’s JSS Medical College explore beneficial effects of sodium butyrate on liver cancer

A recent study by scientists of JSS Medical College in Mysuru has explored the therapeutic potential of sodium butyrate on Hepatocellular Carcinoma (HCC), a major type of liver cancer.

The study recently published in a peer-reviewed journal Biochemical and Biophysical Research Communications (BBRC) shows how short-chain fatty acid sodium butyrate, a natural compound produced by gut microbioata (bacterial population) in the human intestine holds potential for prevention of growth of liver cancer.

“Regular intake of sodium butyrate through fiber-rich daily diet by eating fruits, vegetables, and whole grains helps the gut to produce this protective compound naturally. Such simple dietary habits can strengthen liver health, reduce cancer risk, and support long-term health and wellness,” said a statement by Prasanna K. Santhekadur, professor, Department of Biochemistry, CEMR Lab, JSS Medical College. He led the study with his research students O.C. Samanmitha S. and Shreyas H.K., along with collaborators Rohit Mehtani and Divya Prasanna Kumar.

Liver is one of the largest and vital organs of the human body and acts as a major powerhouse organ, which also controls the function of the brain and heart, and plays an important role in 500 different functions in the human body, silently working day and night to keep us alive and healthy, the statement said.

According to recent research, liver cancer, particularly HCC, is a growing public health concern in India and across the globe, largely driven by sedentary lifestyles, high-calorie diets, excess alcohol consumption, and related metabolic disorders, the statement added.